ea0024oc3.2 | Oral Communications 3 | BSPED2010
Cosgrove K E
, Powell P D
, Bellanne-Chantelot C
, Ellard S
, Clayton P
, Hussain K
, de Lonlay P
, Dunne M J
Congenital hyperinsulinism (CHI) is characterised by unregulated insulin secretion from pancreatic β-cells. The most severe forms are associated with defects in SUR1 and Kir6.2 (encoded by ABCC8 and KCNJ11), which form KATP channels in β-cells. Diazoxide therapy often fails in the treatment of CHI and may be due to reduced cell surface expression of KATP channels. We investigated methods to increase surface expression of KATP<...